Northwestern University Feinberg School of Medicine
Department of Biochemistry and Molecular Genetics
Skip to main content

Events

Dec

14

BMG Seminar: A gatekeeper to DNA amplification - Johnathan R. Whetstine, PhD

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Johnathan R. Whetstine, PhDTepper Family MGH Research ScholarAssociate Professor of MedicineHarvard Medical School and Massachusetts General Hospital Cancer Center DNA copy gains and amplifications are often associated with tumorigenesis, poor prognosis and drug resistance. However, little is known about how these regions of the genome are selected for amplification. Our group discovered that modulation of epigenetic factors and their associated chromatin states control DNA copy gains of drug resistant regions. In fact, transient site-specific copy number gains occur in both normal and cancer cells upon manipulation of a histone H3 lysine 9/36 (H3K9/36) tri-demethylase KDM4A. However, the mechanism by which KDM4A is targeted to specific genomic regions and whether additional chromatin regulators are involved in this process were unknown. To begin addressing these questions, we performed a series of unbiased screens that uncovered insights about how KDM4A targeting influences DNA amplification in the human genome. We also demonstrated that specific epigenetic factors are working as a network to modulate DNA amplification of drug resistant regions of the genome. Furthermore, we uncovered KDM4A-independent DNA amplifications, which established that additional regions are undergoing epigenetic control for amplification. These currently unpublished data will be discussed at the seminar.

more

Jan

18

BMG Seminar: Understanding resistance to therapy in blood cancers in the post-genomic era - Panagiotis Ntziachristos, PhD

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Panagiotis Ntziachristos, PhDAssistant Professor, Department of Biochemistry and Molecular GeneticsNorthwestern University Feinberg School of Medicine T cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive (refractory, relapsed) blood cancer. The focus of our laboratory is to identify and target mechanisms of chemotherapy resistance in high-risk ALL. We show that protein levels of certain oncogenic components (including DNA damage response pathways and the splicing machinery) are aberrantly regulated in T-ALL via a direct interaction with deubiquitinases, in the absence of genetic alterations. This ultimately leads to chemotherapy resistance and disease relapse. In this talk we will discuss the mechanistic underpinnings of non-genomic mechanisms of drug resistance, their use in disease prognosis and ways to therapeutically target them.

more

Jan

19

BMG Journal Club

Chicago - 3:30 PM - 5:00 PM

The BMG Departmental Journal Club Fall 2017 meetings will convene every other Friday from 3:30pm to 5:00pm in Morton 7-660. Each meeting, two members will select articles of their choice from journals in the field to present to attendees. This is an opportunity for us to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience. Pizza and soda are provided.

more

Jan

25

BMG Seminar: Focus on Transcriptional Dysregulation in Myelodysplastic Syndromes and Acute Myeloid Leukemia - Ulrich Steidl, MD, PhD

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Ulrich Steidl, MD, PhDDepartments of Cell Biology and Medicine (Oncology)Albert Einstein College of Medicine/Montefiore Medical Center, NYRelapse continues to be the most common cause of death in acute myeloid leukemia (AML) and many other cancers. Recent evidence has shown that the accumulation of stepwise genetic and epigenetic changes in tissue-specific stem cells lead to the formation of pre-cancerous/pre-leukemic stem cells (pre-LSC) that play a pivotal role not only in disease origination but also in relapse. While the existence and essentiality of such pre-cancerous cell states has been demonstrated in mice and humans, still very little is known about the molecular mechanisms driving pre-LSC formation and progression. We have recently performed molecular studies of pre-leukemic cell states in mouse genetic models as well as primary cells from patients, and discovered new mechanisms of transcriptional dysregulation in pre-LSC in myelodysplastic syndromes (MDS) and AML. We also found that enhancer haplodeficiency and resulting minimal reduction of key transcription factors is sufficient to induce pre-LSC formation and subsequent progression to MDS and AML. Such models provide novel tools for mechanistic study of pre-LSC and their progression to overt MDS and AML, and for the development and testing of pharmacological approaches to therapeutically interfere with these processes. In summary, recent studies have started to shed light on pre-cancerous stem cell states as the earliest origin of various malignancies including MDS and AML, as well as molecular mechanisms driving their formation and progression. These advances provide a basis for the specific therapeutic targeting of pre-cancerous stem cells for the causative treatment of MDS and AML and other cancers.

more

Jan

26

Biochemistry and Molecular Genetics Data Group (BMDG)

Chicago - 3:30 PM - 5:00 PM

Please join us in Morton 7-660 from 3:30pm – 5:00pm for our Biochemistry and Molecular Genetics Data Group (BMDG) meeting. The BMDG meetings provide an opportunity to familiarize ourselves with the work going on in the department, get feedback on ongoing work, and establish new collaborations and identify points of synergy. Pizza and soda will be provided. Please contact Dr. Dan Foltz at dfoltz@northwestern.edu, or Caron Nestler at carson.nestler@northwestern.edu for more details regarding these meetings.  

more

Feb

01

BMG Seminar: Identifying novel driver mutations in pediatric AML using next generation sequencing approaches - Tanja Gruber, MD, PhD

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Tanja Gruber, MD, PhDAssociate Member, Department of Oncology, Division of Molecular OncologySt. Jude Children's Research Hospital

more

Feb

02

BMG Journal Club

Chicago - 3:30 PM - 5:00 PM

The BMG Departmental Journal Club Fall 2017 meetings will convene every other Friday from 3:30pm to 5:00pm in Morton 7-660. Each meeting, two members will select articles of their choice from journals in the field to present to attendees. This is an opportunity for us to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience. Pizza and soda are provided.

more

Feb

08

BMG Seminar: Jaehyuk Choi, MD, PhD

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Jaehyuk Choi, MD, PhDRuth K. Freinkel, MD, Research ProfessorAssistant Professor of Dermatology and Biochemistry and Molecular GeneticsNorthwestern University Feinberg School of Medicine

more

Feb

09

Biochemistry and Molecular Genetics Data Group (BMDG)

Chicago - 3:30 PM - 5:00 PM

Please join us in Morton 7-660 from 3:30pm – 5:00pm for our Biochemistry and Molecular Genetics Data Group (BMDG) meeting. The BMDG meetings provide an opportunity to familiarize ourselves with the work going on in the department, get feedback on ongoing work, and establish new collaborations and identify points of synergy. Pizza and soda will be provided. Please contact Dr. Dan Foltz at dfoltz@northwestern.edu, or Caron Nestler at carson.nestler@northwestern.edu for more details regarding these meetings.  

more

Feb

15

BMG Seminar: Engineering Immunity with Nanotechnology - Gabe A. Kwong, PhD

Chicago - 2:00 PM - 3:00 PM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Gabe A. Kwong, PhDAssistant Professor, Biomedical EngineeringPrincipal Investigator, Laboratory for Synthetic ImmunityGeorgia Institute of Technology and Emory University School of Medicine Human health has been transformed by our ability to engineer immunity – from the pivotal development of the smallpox vaccine to the curative potential of recent cancer immunotherapies. These examples motivate our research program where we merge engineering tools with immunology, creating new biotechnologies to better detect and treat diseases like cancer, organ transplant rejection, and infection. In this seminar, we will broadly describe our research in three vignettes that all leverage advances from nanotechnology: profiling immune repertoires, noninvasive monitoring of immunological health, and engineering T cell based therapies. First, we will describe the development of dynamic antibody-DNA gates for massively multiplexed analysis and sorting of immune cells. Unlike fluorescence based methods, a cytometry framework built on DNA gates can be readily scaled to analyze immune repertoires, such as identifying immunodominant viral epitopes for vaccine design. Second, we are developing activity-based nanoparticles that sense antigen-specific T cell killing in vivo by producing an ultrasensitive signal in urine. In the context of organ transplants, these nanoparticles detect the onset of acute T cell rejection at an early stage when treatments are most effective. Lastly, we will share research where we engineer T cell therapies with thermal gene switches so that their cancer-killing activity can be remotely controlled using pulses of heat. We envision the applications of these technologies will shape an array of immunological systems, and will increase our understanding of the immune system and how it can be controlled in health and disease.

more

Feb

16

BMG Journal Club

Chicago - 3:30 PM - 5:00 PM

The BMG Departmental Journal Club Fall 2017 meetings will convene every other Friday from 3:30pm to 5:00pm in Morton 7-660. Each meeting, two members will select articles of their choice from journals in the field to present to attendees. This is an opportunity for us to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience. Pizza and soda are provided.

more

Feb

22

BMG Seminar: Ash Alizadeh, MD, PhD

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Ash Alizadeh, MD, PhDAssistant Professor, Medicine (Oncology)Stanford University  

more

Feb

23

Biochemistry and Molecular Genetics Data Group (BMDG)

Chicago - 3:30 PM - 5:00 PM

Please join us in Morton 7-660 from 3:30pm – 5:00pm for our Biochemistry and Molecular Genetics Data Group (BMDG) meeting. The BMDG meetings provide an opportunity to familiarize ourselves with the work going on in the department, get feedback on ongoing work, and establish new collaborations and identify points of synergy. Pizza and soda will be provided. Please contact Dr. Dan Foltz at dfoltz@northwestern.edu, or Caron Nestler at carson.nestler@northwestern.edu for more details regarding these meetings.  

more

Mar

01

BMG Seminar: Innate Immune Signaling Dysregulation in Myelodysplastic Syndromes - Daniel Starczynowski, PhD

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Daniel Starczynowski, PhDCo-Leader, Hematologic Malignancies ProgramDivision of Experimental Hematology and Cancer BiologyCincinnati Children’s Hospital  

more

Mar

02

BMG Journal Club

Chicago - 3:30 PM - 5:00 PM

The BMG Departmental Journal Club Fall 2017 meetings will convene every other Friday from 3:30pm to 5:00pm in Morton 7-660. Each meeting, two members will select articles of their choice from journals in the field to present to attendees. This is an opportunity for us to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience. Pizza and soda are provided.

more

Mar

08

BMG Seminar: Jeff Brodsky, PhD

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Jeff Brodsky, PhDAvinoff Professor of Biological SciencesUniversity of Pittsburgh  

more

Mar

09

Biochemistry and Molecular Genetics Data Group (BMDG)

Chicago - 3:30 PM - 5:00 PM

Please join us in Morton 7-660 from 3:30pm – 5:00pm for our Biochemistry and Molecular Genetics Data Group (BMDG) meeting. The BMDG meetings provide an opportunity to familiarize ourselves with the work going on in the department, get feedback on ongoing work, and establish new collaborations and identify points of synergy. Pizza and soda will be provided. Please contact Dr. Dan Foltz at dfoltz@northwestern.edu, or Caron Nestler at carson.nestler@northwestern.edu for more details regarding these meetings.  

more

Mar

15

BMG Seminar: Matthew Vander Heiden, MD, PhD

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Matthew Vander Heiden, MD, PhD Associate Director, Koch Institute for Integrative Cancer ResearchAssociate Professor of BiologyMassachusetts Institute of Technology

more

Mar

16

BMG Journal Club

Chicago - 3:30 PM - 5:00 PM

The BMG Departmental Journal Club Fall 2017 meetings will convene every other Friday from 3:30pm to 5:00pm in Morton 7-660. Each meeting, two members will select articles of their choice from journals in the field to present to attendees. This is an opportunity for us to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience. Pizza and soda are provided.

more

Back to top