Presenting Author:

Bisheng Zhou, Ph.D.

Principal Investigator:

Lisa Wilsbacher, Ph.D.

Department:

Medicine

Keywords:

Sphingosine-1-Phosphate Receptor 1, cardiac hypertrophy, cardiac remodeling, GPCR

Location:

Third Floor, Feinberg Pavilion, Northwestern Memorial Hospital

B41 - Basic Science

Sphingosine 1-Phosphate Receptor 1 regulates pathological cardiac hypertrophy and remodeling

Pathological cardiac hypertrophy, remodeling and subsequent progression to heart failure represents a major cause of morbidity and mortality. While heart failure remains a critical health problem, and the identification of underlying molecular targets and novel protective agents is of crucial importance for improving preventive and therapeutic strategies.Sphingosine-1-Phosphate Receptor 1 (S1P1; encoded by S1pr1) is a G-protein-coupled receptor expressed in multiple cell types in the heart, yet its function in cardiac hypertrophy and remodeling is still not clear. Here in our present study, we analyzed the role of S1P1 in pathological cardiac hypertrophy and remodeling using global S1pr1 heterozygous mice. We observed that mice haploinsufficient for S1P1 show no phenotype at baseline, but they are more prone to developing hypertrophy in the setting of non-ischemic cardiac stress. Furthermore, we detected increased markers of fibrosis, inflammation, ROS, and altered metabolism in hearts from S1pr1 heterozygous mice under pathological stimuli. Therefore, S1P1 seems play an important role in cardiac hypertrophy and remodeling, and may served as a novel target for heart failure.