Mary Beth Donnelley Clinical Pharmacology Core Michael J. Avram, PhD, Director 312-908-0636 mja190@northwestern.edu

Mission Statement

The mission of the Mary Beth Donnelley Clinical Pharmacology Core Facility is to provide state-of-the-art clinical pharmacologic support to Northwestern University investigators as an integral part of bench-to-bedside drug development.  The Core provides pharmacokinetic support for preclinical and clinical studies of cancer chemotherapeutic agents, analgesics, and other small molecules.  Expertise includes optimizing the design, conduct, analysis, interpretation, and reportage of pharmacokinetic studies.  Small molecule concentrations in plasma and other body fluids are measured using an Agilent HPLC system linked to an Applied Biosystems API 3000 triple quadrupole mass spectrometer.  Drug concentration histories are fitted to various compartmental pharmacokinetic models using commercially available and specialized software. 

Consultations:

• Research planning  
• Experimental design
• Grant preparation
• Study conduct
• Data analysis
• Results interpretation
• Manuscript preparation

Services Offered:

• Small molecule concentration measurement in biological fluids
• Pharmacokinetic modeling of drug concentration histories
• Measurement of biomarkers on Aushon Biosystems SearchLight Multiplex Immunoassay Kits  menu (http://www.aushon.com/Resources/Aushon-Menu-of-Assays-Web.pdf)

Location and Contacts:

Michael J. Avram, Ph.D., Diplomate, ABCP, Director
Ward 13-199
Chicago, IL  60611
312-908-0636
mja190@northwestern.edu

Northwestern University Feinberg School of Medicine
Research Office
Chicago, IL 60611
fsm-research@northwestern.edu
(312) 503-1499 Main
(312) 503-5603 Fax

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