The Kim Laboratory is interested in elucidating mechanisms associated with sex steroid hormone action in the female reproductive tract. Additionally, molecular mechanisms associated with aberrant growth of uterine diseases, Endometrial Cancer and Uterine Fibroids are investigated.
Endometrial cancer is the most common gynecologic cancer diagnosed in the United States with an estimated 40,00 new cases resulting in approximately 7,500 deaths. As risk factors for endometrial cancer increase, the incidence of endometrial cancer will also rise, with a paradigm shift to younger ages. In our laboratory, we investigate the role of progesterone receptor in endometrial cancer to ameliorate the tumor's sensitivity to progestins. We are also looking at specific signaling pathways that control progesterone receptor function as potential targets of therapy.
|NIH R01 CA155513: Influence of AKT pathway on progesterone receptor function in endometrial cancer|
Leiomyoma (Uterine Fibroids)
Uterine fibroids, also known as leiomyomas, are benign tumors originating from the myometrium. These tumors can range from a few millimeters to over 20 cm in size. Leiomyomas are common and can occur in up to 77% of women while up to 20% of women suffer from significant morbidity, pain and discomfort, and excessive menstrual bleeding. Leiomyomas are the primary indication for over 200,000 hysterectomies in the United States. In our laboratory we are investigating how the AKT pathway directs activites of ROS in leiomyoma cells. These studies are translated to the identification of important molecules that can be targeted using small molecule inhibitors.
|NIH P01 HD057877: Molecular and functional crosstalk of progesterone receptor and the PI3K/AKT/FOXO pathway in uterine leiomyoma|
Uterus- Building a microphysiological system
The primary goal of this study is to build a human reproductive tract, including the ovary, fallopian tube, uterus, and cervix into a microphysological system that will enable in vitro testing of hormones, drugs and toxic compounds. The Kim Lab is focusing on building three dimensional cocultures of uterine and endocervical cells which will respond to estrogen and progesterone.
|UH2/UH3-NIH: Microphysiologic Systems|
The endocervix is a hormonally responsive tissue that secretes cervical mucus and other proteins in response to hormones during the menstrual cycle. In collaboration with investigators studying HIV transmission (Thomas Hope, Northwestern), this project focuses on identification of hormonally regulated genes that are involved in influencing HIV transmision in the female reproductive tract.
|Gates Foundation: Gene regulation in the Cervix during the menstrual cycle|
Epidemologic and laboratory studies strongly point to a pro-proliferative role of progesterone in the breast. In collaboration with Dr. Seema Khan (Northwestern), this study explores the potential use of selective progesterone receptor modulators for the prevention of breast cancer in high risk women.
|Lynn Sage Foundation: Progesterone antagonists for the prevention of breast cancer.|