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Douglas E. Vaughan, MDIrving S. Cutter Professor and Chair
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Current Research Interests
Dr. Vaughan directs a multidisciplinary research group focused on investigating the role of the plasminogen activator system in cardiovascular disease. Active experimental programs are underway at the molecular and cellular level in animals and in humans. Transgenic and knockout mice are used in a variety of studies designed to explore the tissue-specific expression of PAI-1 in vivo and the role of the fibrinolytic system in vascular disease and tissue remodeling.
Male-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian population.
Schoenhard JA, Asselbergs FW, Poku KA, Stocki SA, Gordon S, Vaughan DE, Brown NJ, Moore JH, Williams SM. Human genetics. 2008 Oct.
Calmodulin kinase II inhibition disrupts cardiomyopathic effects of enhanced green fluorescent protein. Khoo MS, Grueter CE, Eren M, Yang J, Zhang R, Bass MA, Lwin ST, Mendes LA, Vaughan DE, Colbran RJ, Anderson ME. Journal of molecular and cellular cardiology. 2008;44(2):405-10.
Transgenic over-expression of plasminogen activator inhibitor-1 results in age-dependent and gender-specific increases in bone strength and mineralization. Nordstrom SM, Carleton SM, Carson WL, Eren M, Phillips CL, Vaughan DE. Bone. 2007 Dec;41(6):995-1004.
Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity. De Taeye BM, Novitskaya T, McGuinness OP, Gleaves L, Medda M, Covington JW, Vaughan DE. American journal of physiology. Endocrinology and metabolism. 2007;293(3):E713-25.
Plasminogen activator inhibitor-1 has a circadian rhythm in blind individuals. Schoenhard JA, Muldowney JA 3rd, Emens JS, Lewy AJ, Vaughan DE. Thrombosis and haemostasis. 2007;98(2):479-81.
The effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels are dependent on environmental context. Asselbergs FW, Williams SM, Hebert PR, Coffey CS, Hillege HL, Snieder H, Navis G, Vaughan DE, van Gilst WH, Moore JH. Human genetics. 2007.
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View Publications by Doug Vaughan listed in the National Library of Medicine (PubMed). |
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