C. Shad Thaxton, MD, PhD Assistant Professor Department of Urology Translational nanotechnology Curricula: Molecular Biology and Genetics E-mail:   cthaxton003@md.northwestern.edu

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Nanotechnology is the study of the fabrication, directed self-assembly, and characterization of materials that have size dimensions between 1 and 100 nanometers.  In the context of biological nanostructures, this is the size regime of the molecular machinery that constitutes, for example, functional viruses, bacteria, and human cells.  The challenge of bio-nanotechnology and the focus of The Thaxton Laboratory is to control the synthesis of structures that naturally interface with biological systems to develop exquisitely targeted, practical, safe, and effective nanoparticle therapeutics, imaging agents, and biosensors.

Publications:

Nam J.-M.¹, Thaxton, C.S.¹, Mirkin, C. A.  Nanoparticle-Based Biobarcodes For The Ultrasenstive Detection of Proteins. Science 301:1884-1886 (2003). (¹ co-first author)

Thaxton, C.S., Hill, H.D., Georganopoulou, D., Stoeva, S., Mirkin, C.A. A Bio-Barcode Assay Based upon Dithiothreitol Induced Oligonucleotide Release. Anal. Chem. 77(24): 8174-8178 (2005).

Georganopoulou, D., Nam, J.-M., Thaxton, C.S., Chang, L., Klein, W., Mirkin C.A.  Nanoparticle-Based Detection in Cerebral Spinal Fluid of a Soluble Pathogenic Biomarker for Alzheimer's Disease.  Proc. Natl. Acad. Sci. 102(7): 2273-2276 (2005).

Rosi, N., Giljohann, D., Thaxton, C.S., Lytton-Jean, A., Han, M.-S., Mirkin, C.A. Oligonucleotide-Modifed Gold Nanoparticles for Intracellular Gene Regulation. Science. 312 (5776):  1027-1030 (2006).

View Publications by C. Shad Thaxton listed in the National Library of Medicine (PubMed).

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