Dr. Schleimer has a longstanding interest in the mechanisms of action of glucocorticoids in allergic diseases. Past studies have ranged from translational investigations in human subjects to molecular biological assessment of glucocorticoid action. Mechanisms of the pathogenesis of allergic diseases including asthma, rhinosinusitis, dermatitis and others have also been an area of investigation. Recent studies have focused on the role of airway epithelial cells as integrators of responses in the airways, including inflammation, innate immunity and adaptive immunity.
Research topics include:
- Mechanisms of glucocorticoid action in allergic disease
- Role of epithelial activation in allergic disease
- Innate immune responses of airway epithelium
- Regulation of adaptive immune responses by epithelial cells
- Metabolism, distribution and action of glucocorticoid hormones and drugs in the airways
- Mechanisms of the recruitment and activation of inflammatory cells to skin and the airways
Publications:
Peebles RS, Togias A, Bickel C, Diemer FB, Hubbard WC, Schleimer RP. Endogenous glucocorticoids and antigen-induced acute and late phase pulmonary responses. Clin Exp Allergy 30:1257-1265, 2000.
Schleimer RP. Interactions between the hypothalamic-pituitary-adrenal axis and allergic inflammation. J Allergy Clin Immunol 106:S270-274, 2000.
Matsukura S, Stellato C, Georas SN, Casolaro V, Plitt JR, Miura K, Kurosawa S, Schindler U, Schleimer RP. Interleukin-13 upregulates eotaxin expression in airway epithelial cells by a STAT6-dependent mechanism. Am J Respir Cell Mol Biol 24:755-761, 2001.
Liu MC, Proud D, Lichtenstein LM, Hubbard WC, Bochner BS, Stealey BA, Breslin L, HuiQuing X, Friedhoff L, Schroeder JT, Schleimer R.P. Effects of prednisone on the cellular responses and release of cytokines and mediators after segmental allergen challenge of asthmatic subjects. J Allergy Clin Immunol 108:29-38, 2001.
Kurosawa S, Myers AC, Chen L, Wang S, Ni J, Plitt JR, Heller NM, Bochner BS, Schleimer RP. Expression of the costimulatory molecule B7-H2 (inducible costimulator ligand) by human airway epithelial cells. Am J Respir Cell Mol Biol 28:563-573, 2003
Sha Q, Truong-Tran AQ, Plitt JR, Beck LA, Schleimer RP. Activation of airway epithelial cells by Toll-like receptor agonists. Am J Respir Cell Mol Biol 31:358-64, 2004.
Heller NM, Matsukura S, Georas SN, Boothby MR, Rothman PB, Stellato C, Schleimer RP. Interferon-g inhibits STAT6 signal trasduction and gene expression in human airway epithelial cells. Am J Respir Cell Mol Biol 31:573-582, 2004.
Kim J, Myers AC, Chen L, Pardoll D, Truong-Tran QA, Lane A, McDyer J, Furtuno L, Schleimer RP. Constitutive and inducible expression of B7 familty of ligands by human airway epithelial cells. Am J Respir Cell Mol Biol 2005:Jun 16:[Epub ahead of print] PMID 15961727.
