My research interests are in the field of cytokine-signaling in malignant cells. We have identified and characterized several novel signaling cascades activated by the Type I interferon receptor in leukemia and other neoplastic cells, including the insulin receptor substrate (IRS)-pathway, the Crk-pathway and the p38 Map kinase signaling cascade. A major interest of our group is to determine the mechanisms by which chronic myelogenous leukemia (CML) cells become refractory to the antiproliferative effect of interferons and the mechanisms of synergy between interferon and STI571. Other research areas in which my laboratory is actively engaged are the mechanisms of signal transduction of all-trans-retinoic acid (ATRA) and arsenic trioxide in acute promyelocytic leukemia. We also study the signaling mechanisms of regulation of normal hematopoiesis by myelosuppressive cytokines, including interferons, tumor necrosis factor-alfa and transforming growth factor-beta.
Selected Publications:
Katsoulidis, E., Carayol, N., Woodard, J., Konieczna, I., Majchrzak-Kita, B., Jordan, A., Sassano, A., Eklund, E.A., Fish, E.N., and Platanias, L.C. (2009) Role of Schlafen 2 (SLFN2) in the generation of IFN{alpha}-induced growth inhibitory responses. J.Biol. Chem. Jul 10. [Epub ahead of print] PubMed PMID: 19592487.
Joshi, S., Kaur, S., Redig, A.J., Goldsborough, K., David, K., Ueda, T., Watanabe-Fukunaga, R., Baker, D.P., Fish, E.N., Fukunaga, R., and Platanias, L.C. (2009) Type I interferon (IFN)-dependent activation of Mnk1 and its role in the generation of growth inhibitory responses. Proc. Natl. Acad. Sci. U. S. A. 106:12097-12102.
Platanias, L.C. (2009) Biological responses to arsenic compounds. J. Biol. Chem. 284:18583-18587.
Kroczynska, B., Kaur, S., Katsoulidis, E., Majchrzak-Kita, B., Sassano, A., Kozma, S.C., Fish, E.N., and Platanias, L.C. (2009) Interferon-dependent engagement of eukaryotic initiation factor 4B via S6 kinase (S6K)- and ribosomal protein S6K-mediated signals. Mol Cell Biol. 29:2865-2875.
Redig, A.J., Sassano, A., Majchrzak-Kita, B., Katsoulidis, E., Liu, H., Altman, J.K., Fish, E.N., Wickrema, A., and Platanias, L.C. (2009) Activation of protein kinase C{eta} by type I interferons. J. Biol. Chem. 284:10301-10314.
Kaur, S., Sassano, A., Joseph, A.M., Majchrzak-Kita, B., Eklund, E.A., Verma, A., Brachmann, S.M., Fish, E.N., and Platanias, L.C. (2008) Dual regulatory roles of phosphatidylinositol 3-kinase in IFN signaling. J. Immunol. 181:7316-7323.
Kaur, S., Sassano, A., Dolniak, B., Joshi, S., Majchrzak-Kita, B., Baker, D.P., Hay, N., Fish, E.N., and Platanias, L.C. (2008) Role of the Akt pathway in mRNA translation of interferon-stimulated genes. Proc. Natl. Acad. Sci. U.S.A. 105:4808-1413.
