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Franck Mauvais-Jarvis, MD, PhDAssociate Professor of Medicine
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Our laboratory focuses on identifying the cellular and molecular mechanisms by which sex hormones influence the risks of obesity and diabetes. We use genetic, molecular and physiological tools to study mice with conditional knockouts of the estrogen or/and androgen receptor as well as cell culture models in highly controlled environments.
Ongoing projects in our laboratory include but are not limited to: 1) studies of estrogen genomic and non-genomic actions in modulating insulin secretion, insulin action and fat metabolism; 2) studies of androgen actions in the development of insulin resistance, insulin deficiency, diabetes and obesity; 3) studies of the antidiabetic and anti-obesity actions of estrogen receptor and androgen receptor modulators (SERMs, SARMs) in mice; 4) Studies of estrogen receptor ligands in protecting human islet survival in vitro to improve islet transplantation outcome in mouse models of type 1 diabetes.
Our goal is 1) to obtain a better understanding of the biological processes at the root of diabetes and obesity, from the molecular standpoint to the population levels, 2) to determine how to modulate sex steroid actions in a tissue-specific manner in order to have a therapeutic impact on these diseases.
Mauvais-Jarvis F., Ueki K., Fruman D.A., Miller K.E., Iannacone M., Accili D., Cantley L.C. and Kahn C.R.: Reduction in the p85alpha Isoform of Phosphoinositide 3-Kinase Improves Insulin Signaling and Ameliorates Diabetes in Mice. J. Clin. Invest. 2002. Jan ; 109: 141-149
Cariou B, Postic C, Boudou P, Burcelin R, Kahn CR, Girard J, Burnol AF, Mauvais-Jarvis F. Cellular and molecular mechanisms of adipose tissue plasticity in muscle-specific insulin receptor knockout mice. Endocrinology. 2004 Apr;145(4):1926-32.
Le May C, Chu K, Hu M, Ortega CS, Simpson ER, Korach KS, Tsai MJ, Mauvais-Jarvis F. Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin deficient diabetes in mice. Proc Natl Acad Sci U S A. 2006. Jun 13;103(24):9232-7.
Liu S, Le May C, Wong WP, Ward RD, Clegg DJ, Marcelli M, Korach KS, Mauvais-Jarvis F. Importance of extranuclear estrogen receptor-{alpha} and membrane G protein-coupled estrogen receptor in pancreatic islet survival. Diabetes. 2009 Jul 8. [Epub ahead of print]
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View Publications by Franck Mauvais-Jarvis listed in the National Library of Medicine (PubMed). |
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