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Jonathan C.R. Jones, PhDProfessor
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Communication between cells and the environment is essential for development, homeostasis and repair of tissues. Our research in this area focuses on the interaction between epithelial cells and the extracellular matrix. One of our primary goals is to define how members of the laminin family of matrix molecules and their receptors regulate the behavior of skin and lung cells in normal and diseased tissues.
One of our funded projects involves studying how cell surface receptors of the integrin family determine the precise pattern of deposition and assembly of laminin matrix in the skin. This matrix is key to the regulation of specific motile behavior patterns of keratinocytes and, thus, our studies have implications for skin wound healing and cancer. Our analyses involve molecular genetics, dissection of signaling cascades and live cell imaging. Indeed, we have pioneered the visualization of laminin matrix assembly by live cells.
In a second project, undertaken in collaboration with colleagues from the Division of Pulmonary and Critical Care Medicine, we have uncovered novel functions for laminin matrix in the transduction of mechanosignals in the alveolar epithelial compartment of the lung. We are currently working on how laminin regulates alveolar epithelial cell differentiation and how genetic manipulation of signaling pathways in alveolar epithelial cells impacts normal and diseased lung function in vivo.
Jones, J.C.R., Lane, K., Hopkinson, S.B., Lecuona, E., Geiger, R.C., Dean, D.A., Correa-Meyer, E., Gonzales, M., Campbell, K., Sznajder, J.I. and Budinger, S. (2005). Laminin-6 assembles into multimolecular fibrillar complexes with perlecan and participates in mechano-signal transduction via a dystroglycan-dependent, integrin-independent, mechanism. J. Cell Sci. 118: 2557-2565. PMID: 15928048
DeBiase, P.J., Lane, K., Budinger, S., Ridge, K., Wilson, M., and Jones, J.C.R. (2006). Laminin-331 (laminin-6) fiber assembly by type I-like alveolar cells. J. Histo. Cytochem., 54: 665 - 672. PMID: 16714422
Sehgal, B.U., Debiase, P., Matzno, S., Chew, T-L., Claiborne, J.N., Hopkinson, S.B., Russell, A., Marinkovich, P.M., and Jones, J.C.R. (2006). Integrin b4 regulates migratory behavior of keratinocytes by determining laminin-332 (laminin-5) matrix organization. J. Biol. Chem. 281:35487-35498. PMID: 16973601
Sugawara, K., Tsuruta, D., Kobayashi, H., Ikeda, K. Hopkinson, S.B., Jones, J.C.R. and Ishii, M. (2007). Spatial and temporal control of laminin-5 (332) and -10 (511) expression during the induction of anagen hair growth: Evidence for laminin-mediated regulation of hair elongation. J. Histo. Cytochem. 55: 43-55. PMID: 16957169
Kligys, K., Claiborne, J.N., DeBiase, P., Hopkinson, S.B., Wu, Y., Mizuno, K. and Jones, J.C.R. (2007). The Slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization and motility behavior of keratinocytes. J. Biol. Chem. 282: 32520-32528. PMID: 17848544
Hopkinson, S.B., DeBiase, P.J., Kligys, K., Hamill, K. and Jones, J.C.R. (2008). Fluorescently tagged laminin subunits facilitate analyses of the properties, assembly and processing of laminins in live and fixed lung epithelial cells and keratinocytes. Matrix Biol. 27: 640-647. PMID: 18617003
Gonzalez, A., Clairborne, J.N. and Jones, J.C.R. (2008). Integrin crosstalk in endothelial cells is regulated by protein kinase A and protein phosphatase 1. J. Biol. Chem. 283: 31849-31860. PMID: 18806263
Budinger, G.R.S., Urich, D., DeBiase, P.J., Chiarella, S., Burgess, Z., Baker, C., Soberanes, S., Mutlu, G.M. and Jones, J.C.R. (2008). Stretch induced activation of AMP kinase in the lung requires dystroglycan. Am. J. Resp. Cell Mol. Biol. 39: 666-672. PMID: 18556591
Bhattacharya, R., Gonzalez, A., DeBiase, P.J., Goldman, R.D., Flitney, F.W. and Jones, J.C.R. (2009). Recruitment of vimentin to the cell surface by b3 integrin and plectin mediates adhesion strength. J. Cell Sci. 122: 1390-1400. PMID: 19366731
Kligys, K., Yun, J., Yu, D. and Jones, J.C.R. 14-3-3ζ/τ heterodimers regulate Slingshot activity in migrating keratinocytes. Biochem. Biophys Res. Comm. 383: 450-454. PMID: 19371722
Hamill, J.J., Hopkinson, S.B., DeBiase, P. and Jones, J.C.R. BPAG1e maintains keratinocyte polarity through β4 integrin-mediated modulation of Rac 1 and cofilin activities. Mol. Biol. Cell., 20: 2954-2962. PMID: 19403692
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View Publications by Jonathan Jones listed in the National Library of Medicine (PubMed). |
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