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Hossein Ardehali, MD, PhDAssistant Professor
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To visit the Ardehali Lab website click here.
The focus of our laboratory is to study the role of mitochondria and cellular metabolism in cardiovascular disease. We specifically work on the following projects:
Analysis of the role of the mitochondrial ATP-binding cassette protein-1 (mABC1) in cellular protection. mABC1 is a mitochondrial membrane protein, whose function is not characterized. In preliminary studies, we have shown that mABC1 plays a protective role in isolated cardiomyocytes. We are currently studying the function of this protein.
Hexokinases and cell death. Hexokinases carry out the initial step in the process of glucose metabolism. They also bind to the mitochondrial membrane and prevent traslocation of pro-apoptotic molecules (such as Bax) into the mitochondria. This process, which is not fully understood, is the focus of our studies.
Functional characterization of sucrose nonfermenting-1 (SNF1) related kinase (SNRK). SNRK is a novel protein with sequence homology to AMP kinases, however, its function is not delineated. We are conducting several studies to characterize the primary function of this protein.
Role of microRNAs in myocardial ischemic damage. MicroRNAs are known to play a major role in various human disorders. We are studying changes in microRNA profile in myocardial cells in response to hypoxia.
Gordon, L., Singh, A., Prachand, S., Lieberman, E., Sun, L., Burke, M.A., Naik, T.J., Prasad, S., Ardehali, H. 2008. Blockade of the erbB2 Receptor Induces Cardiomyocyte Death through Mitochondrial and Reactive Oxygen Species-dependent Pathways.. J. Biol Chem, 284(4):2080-7.
Burke MA, Mutharasan RK, Ardehali H. 2008. The sulfonylurea receptor, an atypical ATP-binding cassette protein, and its regulation of the KATP channel. Circ Research 102(2):164-76.
Sun, L., Shukair, S., Naik, T.J., Moazed, F., Ardehali, H. 2008. Glucose phosphorylation and mitochondrial binding are required for the protective effects of hexokinase I and II. Mol. Cell. Biol. 28(3):1007-17.
Ardehali, H., O’Rourke, B, Marban, E. 2005. Cardioprotective role of the mitochondrial ATP-binding cassette protein-1. Circ Research 97(8):740-2.
Ardehali, H., Chen, Z., Ko, Y., Mejia-Alvarez, R., Marbán, E. 2004. Multiprotein complex containing succinate dehydrogenase confers mitochondrial ATP-sensitive K+ channel activity. PNAS 101(32): 11880-5.
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View Publications by Hossein Ardehali listed in the National Library of Medicine (PubMed). |
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