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Hossein Ardehali, MD, PhDAssistant Professor
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To visit the Ardehali Lab website click here.
The focus of our laboratory is to study the role of mitochondria and cellular metabolism in cardiovascular disease. We specifically work on the following projects:
Analysis of the role of the mitochondrial ATP-binding cassette protein-1 (mABC1) in cellular protection. mABC1 is a mitochondrial membrane protein, whose function is not characterized. In preliminary studies, we have shown that mABC1 plays a protective role in isolated cardiomyocytes. We are currently studying the function of this protein.
Hexokinases and cell death. Hexokinases carry out the initial step in the process of glucose metabolism. They also bind to the mitochondrial membrane and prevent traslocation of pro-apoptotic molecules (such as Bax) into the mitochondria. This process, which is not fully understood, is the focus of our studies.
Functional characterization of sucrose nonfermenting-1 (SNF1) related kinase (SNRK). SNRK is a novel protein with sequence homology to AMP kinases, however, its function is not delineated. We are conducting several studies to characterize the primary function of this protein.
Role of microRNAs in myocardial ischemic damage. MicroRNAs are known to play a major role in various human disorders. We are studying changes in microRNA profile in myocardial cells in response to hypoxia.
Sun L, Shukair S, Naik TJ, Moazed F, Ardehali H., Glucose phosphorylation and mitochondrial binding are required for the protective effects of hexokinase I and II. Mol Cell Biol. 2007 Nov 26; [Epub ahead of print]
Ardehali H, O'Rourke B, Marbán E. Cardioprotective role of the mitochondrial ATP-binding cassette protein 1. Circ Res. 2005 Oct 14;97(8):740-2.
Ardehali H, Chen Z, Ko Y, Mejía-Alvarez R, Marbán E. Multiprotein complex containing succinate dehydrogenase confers mitochondrial ATP-sensitive K+ channel activity. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11880-5.
Ardehali H, Printz RL, Whitesell RR, May JM, Granner DK. Functional interaction between the N- and C-terminal halves of human hexokinase II. J Biol Chem. 1999 Jun 4;274(23):15986-9.
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View Publications by Hossein Ardehali listed in the National Library of Medicine (PubMed). |
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