Northwestern University Feinberg School of Medicine
Faculty Profiles
Yong  Wan, PhD

Yong Wan, PhD

Professor of Obstetrics and Gynecology and Pharmacology

Focus of Work

Bio

The overarching goal of Wan laboratory is to define the molecular mechanisms of breast tumor initiation, progression, and metastasis, and to identify novel targets for therapeutic development. Particularly, the laboratory seeks to address how defects in the ubiquitin-proteasome system and other posttranslational modifiers such as protein methyltransferase and poly (ADP-ribose) polymerase would result in genomic instability, abnormal cell cycle, and aberrant signaling that predispose otherwise no...[Read full text]The overarching goal of Wan laboratory is to define the molecular mechanisms of breast tumor initiation, progression, and metastasis, and to identify novel targets for therapeutic development. Particularly, the laboratory seeks to address how defects in the ubiquitin-proteasome system and other posttranslational modifiers such as protein methyltransferase and poly (ADP-ribose) polymerase would result in genomic instability, abnormal cell cycle, and aberrant signaling that predispose otherwise normal cells to become cancerous tumor cells or promote cancer metastasis. The research approaches in Wan laboratory include biochemical, cell biological, genetic, protein structural analyses as well as the use of breast cancer animal models and analyses of clinical specimens.[Shorten text]

Education and Certification

  • PhD: Cornell University, Molecular Biology & Biochemistry (1997)
  • Postdoctoral Fellowship: Harvard University, Proteolysis/Cancer Biology (2003)

Contact

312-503-2769

Robert H Lurie Medical Research Center Room 10-117
303 E Superior
Chicago IL 60611