Northwestern University Feinberg School of Medicine
Faculty Profiles
Athanasios  Vasilopoulos, PhD

Athanasios Vasilopoulos, PhD

Assistant Professor of Radiation Oncology

Focus of Work

Bio

My primary research focus is the study of the genetic and biochemical connection between Sirtuins and carcinogenesis as well as tumor cell resistance. To address the idea that there may be a connection between sirtuin genes and carcinogenesis, we try to elucidate the potential mechanistic relationship between sirtuins and specific targets and/ or signaling pathways involved in the development of age-related diseases such as cancer. Sirtuins are the homologous genes of yeast sir2 and previous stu...[Read full text]My primary research focus is the study of the genetic and biochemical connection between Sirtuins and carcinogenesis as well as tumor cell resistance. To address the idea that there may be a connection between sirtuin genes and carcinogenesis, we try to elucidate the potential mechanistic relationship between sirtuins and specific targets and/ or signaling pathways involved in the development of age-related diseases such as cancer. Sirtuins are the homologous genes of yeast sir2 and previous studies suggest that sirtuins may play a role in longevity. Mammals contain seven sirtuins (Sirt1-7), which are categorized by their highly conserved central NAD+-binding and histone deacetylase catalytic domain, that play a role in multiple cellular pathways including metabolism, DNA repair, inflammation, and cellular survival via targeting histones and non-histone proteins such as p53, Foxo family, PGC1a, NF-¿B, ku70/86, etc. Thus, besides the role of sirtuins in longevity, it is of great interest to be tested whether there is any role of sirtuins in age-related diseases including cancer. Indeed, knockout mice of each one of the sirtuins (Sirt1-7) exhibit multiple defects such as lethality (Sirt1), tumorigenesis (Sirt2), tumorigenesis and aberrant metabolism (Sirt3), insulin resistance (Sirt4), aberrant urea metabolism (Sirt5), premature aging and aberrant metabolism (Sirt6), and cardiac hypertrophy (Sirt7), suggesting that indeed sirtuins are key regulators of cellular homeostasis and are implicated in controlling critical physiological functions.[Shorten text]

Keywords


Education and Certification

  • PhD: University of Athens, Animal Physiology (2005)

Contact

Robert H Lurie Medical Research Center Room 6-117
303 E Superior
Chicago IL 60611