Northwestern University Feinberg School of Medicine
Faculty Profiles
Steven T Kosak, PhD

Steven T Kosak, PhD

Assistant Professor of Cell and Molecular Biology

Focus of Work

Academic Focus

My research group is keenly interested in untangling the relationship between the form and function of the human genome within the nucleus. To this end, we are developing methods and experimental strategies to analyze dynamic genomic reorganization in multiple models of cellular differentiation, including myogenesis, neurogenesis, and epidermal differentiation. We are specifically interested in inter- and intra-chromosomal associations as a function of lineage-restricted gene expression and li...[Read full text]My research group is keenly interested in untangling the relationship between the form and function of the human genome within the nucleus. To this end, we are developing methods and experimental strategies to analyze dynamic genomic reorganization in multiple models of cellular differentiation, including myogenesis, neurogenesis, and epidermal differentiation. We are specifically interested in inter- and intra-chromosomal associations as a function of lineage-restricted gene expression and linear gene arrangement. In addition, we are investigating: (1) gene polarity in nuclei within polarized cell types, (2) co-translational mRNA surveillance and protein quality control in the nucleus in models of neurodegeneration, (3) a role for homologous chromosome association in autoimmune disease, and (4) the role of a novel chromosome end structure in replicative aging and human progeroid syndromes.[Shorten text]

Education and Certification

  • PhD: University of Chicago, Molecular Genetics (2001)
  • Postdoctoral Fellowship: Fred Hutchinson Cancer Research Center (2008)

Contact

312-503-9582

Ward Building Room 8-132
303 E Chicago Avenue
Chicago IL 60611