Northwestern University Feinberg School of Medicine
Faculty Profiles
Barbara M Buttin, MD

Barbara M Buttin, MD

Health System Clinician of Obstetrics and Gynecology (Gynecologic Oncology)

Focus of Work

Bio

Recently, Dr. Buttin received a two-year award from the Sidney Kimmel Foundation for Cancer Research for her work studying molecular mechanisms that influence cell growth and metastasis in an aggressive subtype of endometrial cancer, uterine papillary serous carcinoma (UPSC). This work has since led to an additional grant from the National Cancer Institute as well as several smaller, foundation grants. She has authored several research articles on a novel biomarker to predict chemosensitivity an...[Read full text]Recently, Dr. Buttin received a two-year award from the Sidney Kimmel Foundation for Cancer Research for her work studying molecular mechanisms that influence cell growth and metastasis in an aggressive subtype of endometrial cancer, uterine papillary serous carcinoma (UPSC). This work has since led to an additional grant from the National Cancer Institute as well as several smaller, foundation grants. She has authored several research articles on a novel biomarker to predict chemosensitivity and prognosis in UPSC as well as the role of defective DNA mismatch repair and hereditary cancer susceptibility in endometrial cancer focusing specifically on the MSH6 DNA mismatch repair gene. Her current basic research includes the elucidation of pathways of carcinogenesis in uterine papillary serous carcinoma, its association with inherited cancer syndromes, as well as the prevalence of defective DNA mismatch repair in type II endometrial cancer. Her clinical research focuses on the development of synuclein-gamma (SNCG) as a novel prognostic biomarker for high risk endometrial cancer and its association with chemoresistance. Dr. Buttin is collaborating with the Gynecologic Oncology Group (GOG) and has a special interest in novel chemotherapy and targeted agents for endometrial, cervical and ovarian cancer, treatment strategies for uterine sarcomas, as well as the role of radical surgery and minimally invasive surgery in the management of gynecologic malignancies.[Shorten text]

Keywords


Education and Certification

  • MD: Hahnemann University (1998)
  • Residency: Washington University Medical Center (2002)
  • Fellowship: Washington University Medical Center (2005)

Contact

312-695-0990

NMH/Prentice Women's Hospital Room 05-2168
250 E Superior
Chicago IL 60611