Northwestern University Feinberg School of Medicine
Faculty Profiles
Tomoko  Hayashida, MD, PhD

Tomoko Hayashida, MD, PhD

Research Associate Professor of Pediatrics (Kidney Diseases)

Focus of Work

Bio

Chronic kidney disease (CKD) affects approximately 20% of US population. Primary causes for CKD varies from genetic disorder to metabolic problems, but many are unknown. Regardless of the primary cause, CKD progresses with two essential phases; injury to podocyte, the primary barrier for filtration units of kidney, and progressive scarring of kidney, which would eventually obliterate the filtration units and lead to loss of kidney function.
My research goal is to understand the molecular mechani...[Read full text]
Chronic kidney disease (CKD) affects approximately 20% of US population. Primary causes for CKD varies from genetic disorder to metabolic problems, but many are unknown. Regardless of the primary cause, CKD progresses with two essential phases; injury to podocyte, the primary barrier for filtration units of kidney, and progressive scarring of kidney, which would eventually obliterate the filtration units and lead to loss of kidney function.
My research goal is to understand the molecular mechanisms underlining these two features of CKD in order for developing novel therapeutic approaches for CKD.

To address the first phase podocyte injury, we are currently working on a molecule called p110g. Our data suggest that a specific inhibitor of this molecule may provent podocyte injury.
For the second, scarring phase, my previous works revealed several pathways that modulate functions of a scar-promoting cytokine, TGF-beta. Now, we have identified a molecule called SARA is a critical gate keeper to prevent cells from becoming scar forming cells.
Since in most cases patients seek to medical care when the initial injury had already occurred, targeting SARA might be beneficial approach treating CKD.[Shorten text]

Keywords


Education and Certification

  • MD: Keio University Medical School (1988)
  • PhD: Keio University Medical School, Medical Science (2004)

Contact

312-503-0089

Searle Building Room 4-491
320 E Superior
Chicago IL 60611