Northwestern University Feinberg School of Medicine
Faculty Profiles
Marilyn L Lamm, PhD

Marilyn L Lamm, PhD

Research Assistant Professor of Pediatrics (Developmental Biology)

Focus of Work

Bio

Understanding the intricate signaling interactions among cancer cells, stromal cells, and the collagen extracellular matrix will lead to effective diagnostic and therapeutic strategies against cancer progression, metastasis and the development of drug resistance. Our research has previously investigated reciprocal cross-talk between invading cancer cells and host bone stromal cells that contribute to metastatic tumor development. We investigated the role of the Sonic hedgehog - Gli pathway in ...[Read full text]Understanding the intricate signaling interactions among cancer cells, stromal cells, and the collagen extracellular matrix will lead to effective diagnostic and therapeutic strategies against cancer progression, metastasis and the development of drug resistance. Our research has previously investigated reciprocal cross-talk between invading cancer cells and host bone stromal cells that contribute to metastatic tumor development. We investigated the role of the Sonic hedgehog - Gli pathway in paracrine interactions between cancer cells and bone cells. Sonic hedgehog (Shh) is a member of the hedgehog family of ligands that activate an intracellular signaling cascade upon binding to transmembrane receptors (Patched) leading to transcriptional regulation of specific target genes by the Gli family of transcription factors. We have demonstrated that paracrine Shh-Gli signaling between prostate cancer cells and bone cells promote bone cell or osteoblast differentiation, a hallmark of prostate cancer metastasis in bone. We have provided evidence that osteoblasts elaborate a different kind of collagen extracellular matrix in the presence of Shh-expressing prostate cancer cells. The structural properties of collagen matrix in bone impact cancer cell functions. We now extend our research into understanding paracrine signaling mechanisms in pediatric cancers including osteosarcoma, the most common primary bone tumor in children and young adults. Our present goal is to understand the role of cancer cell - stromal cell - extracellular matrix interactions in drug chemoresistance in pediatric cancers and the potential role of Gli transcriptional regulation.[Shorten text]

Keywords


Education and Certification

  • PhD: University of Illinois - Urbana, Physiology (1988)

Contact

773-755-6569
773-755-7322

Stanley Manne Children’s Research Institute Box 204
225 East Chicago Avenue
Chicago IL 60611