H. William  Schnaper, MD

H. William Schnaper, MD

Professor of Pediatrics (Kidney Diseases)



Morton Building Room 4-685G
310 E Superior
Chicago IL 60611

schnaper( at )northwestern.edu

Education/Research Website

Hospital Affiliations

I am on the medical staff at the following Feinberg-affiliated hospital(s)

Education and Certification

MD: University of Maryland (1975)
Residency: Mt. Sinai Hospital-NY, Pediatrics (1978)
Fellowship: Saint Louis Children's Hospital, Pediatrics Nephrology (1982)
Board Certification: Pediatric Nephrology, Pediatrics


Description of Interests

Our laboratory seeks to understand the mechanisms of fibrosis that occur in chronic, progressive kidney disease. We have been studying the role of transforming growth factor (TGF-ß) because it has been associated with a number of kidney diseases. However, the classically described TGF-ß/Smad signaling pathway is too simple to account for the multiple, sometimes contradictory effects of TGF-ß on cell function. Therefore, we have sought to understand how cell phenotype and the molecular “signature” of a cell determine whether TGF-ß signaling leads to fibrosis. We have identified a number of non-canonical signaling pathways that interact with classical Smad signaling, and begun to establish the hierarchy among these pathways. We are studying the manipulation of these pathways in vitro and in mouse models in an effort to translate our basic findings into therapeutic approaches to halting or preventing the progression of kidney disease.

Interests (Keywords)

Extracellular Matrix; Fibrosis; Kidney; Signal Transduction; TGF-beta

Research and Publications

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