Northwestern University Feinberg School of Medicine
Faculty Profiles
Annette  Gilchrist, PhD

Annette Gilchrist, PhD

Adjunct Assistant Professor of Pharmacology

Focus of Work

Bio

My work focuses on G protein coupled receptors (GPCRs). This large family of nearly 1000 receptors is responsible for critical signaling components in normal cellular physiology responses such as differentiation, chemotaxis, and apoptosis. In fact, nearly half the drugs an the market today are directed at members of this important family of receptors. I study how they signal to the cognate partner, the heterotrimeric G protein using novel tools (ie US patent
6,559,128) as well as other signal...[Read full text]
My work focuses on G protein coupled receptors (GPCRs). This large family of nearly 1000 receptors is responsible for critical signaling components in normal cellular physiology responses such as differentiation, chemotaxis, and apoptosis. In fact, nearly half the drugs an the market today are directed at members of this important family of receptors. I study how they signal to the cognate partner, the heterotrimeric G protein using novel tools (ie US patent
6,559,128) as well as other signaling partners such as arrestin. A key part of my research is directed at allosteric modulators, compounds which can modulate GPCR signaling at a site distinct from the ligand binding site.[Shorten text]

Keywords


Education and Certification

  • PhD: University of Connecticut, Immunology (1995)
  • Postdoctoral Fellowship: University of Illinois, Chicago (1999)

Contact

312/503-4892

Searle Building Room 5-474
320 E Superior
Chicago IL 60611