Dr. Zhang was appointed as Research Assistant Professor of Urology in 2004. He graduated with an MD from Fujian Medical University (PRC) in 1993 and went on to complete his general surgery and urology residency training there. Dr. Zhang earned his PhD from Peking University in Beijing in 2001. He continued his training with a 2-year postdoctoral fellowship at Northwestern University, which was funded through an American Foundation for Urologic Disease (AFUD) scholarship. Dr. Zhang’s research interests include prostate cancer immunotherapy by adoptive transfer of tumor reactive TGF-beta-insensitive CD8+ T cells and methylation of the promoters of TGF-beta receptors.

Education

Medical School: Fujian Medical University, Fuzhou, Fujian, PRC
Surgery Residency: Fujian Medical University, Fuzhou, Fujian, PRC
Urology Residency: Fujian Medical University, Fuzhou, Fujian, PRC
Graduate: Urology, Molecular and Cell Biology, Institute of Urology, Peking University, Bejing, PRC
Post-graduate: Molecular Biology & Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL

Selected Publications
The following publications are selected from a total of 50 journal articles.  For more information on Dr. Zhang's scholarly productivity, please contact his office.

Journal Articles

1. Zhang Q, Chen Z, Shi Z, et al. The expression of GST-pi and DNA topoisomerase II in renal cell carcinoma and its significance. Chin J Surg. 37(8):512-5. 1999.
2. Zhang Q, Chen Z, Shi Z, et al. Expression of topoisomerase II in renal cell carcinoma and its clinical significance. Chin J Clin Exp Pathol. 15(6):501-4. 1999.
3. Zhang Q, Chen Z, Shi Z, et al. Expression of P-glycoprotein and topoisomerase II in renal cell carcinoma and its clinical implication. Chin J Exp Surg. 16(5):470-3. 1999.
4. Zhang Q, Chen Z, Shi Z, et al. Expression of glutathione-S-transferase-pi in primary renal cell carcinoma and its clinical significance. J Fujian Med Univ. 12(33):372-6. 1999.
5. Zhang Q, Chen Z, Shi Z, et al. Mechanism of drug resistance of primary renal cell carcinoma and their significance. Chin J Oncol. 22(2):145-8. 2000.
6. Zhang Q, Zhang Z, Guo Y, et al. Use of suppression subtractive hybridization strategy for cloning and identifying specifically expressed genes of renal cell carcinoma. Chin Sci Bull. 45(16):1758-62. 2000.
7. Zhang Q, Zhang Z, Guo Y, et al. Cloning of renal cell related genes: construction of a cDNA subtractive library of human renal cell carcinoma and its significance. Chin Prog Biochem Biophys. 27(3):301-4. 2000.
8. Zhang Q, Zhang Z, Guo Y, et al. Supression subtractive hybridization and oncogenes clone. Foreign Med Sci Cancer Sect. 27(6):362-4. 2000.
9. Zhang Q, Zhang Z, Guo Y, et al. The progression in research about renal cell carcinoma relative genes. Chin J Urol. 22(5):313-5. 2001.
10. Zhang Q, Chen L, Guo Y, et al. Study of the expression of renal cell carcinoma relative novel gene GYLZ-RCC18 and its role in growth and proliferation of renal cell carcinoma. Chin J Exp Surg. 18(5):450-3. 2001.
11. Zhang Q, Ai J, Liang L, et al. The significance of transfection of GYLZ-RCC18 antisense oligonucleotide on RCC cell line GRC-1. Chin J Urol. 22(10):581-3. 2001.
12. Zhang Q, Zhang Z, Guo Y. Construction of renal cell carcinoma cDNA subtractive library and cloning of renal cell carcinoma relative genes. Chin J Exp Surg. 18(4):338-40. 2001.
13. Zhang Q, Zhang Z, Guo Y, et al. Anti-dead effect of renal cell carcinoma related novel gene GYLZ-RCC18 on renal cell carcinoma cell line GRC-1. Chin J Surg. 39(5):398-400. 2001.
14. Zhang Q, Zhang Z, Guo Y, et al. Use of suppression subtractive hybridization strategy for cloning and identifying specifically expressed genes of renal cell carcinoma. Chin Sci Bull. 46(3):226-9. 2001.
15. Zhang Q, Zhang Z, Guo Y, et al. Suppression subtractive hybridization for identifying differentially expressed genes in renal cell carcinoma. Chin Med J. 114(8):807-12. 2001.
16. Zhang Q, Zhang Z, Guo Y, et al. Cloning and identifying renal cell carcinoma differentially expressed genes and their significance. Chin Med J. 81(6):356-9. 2001.
17. Zhang Q, Zhang Z, Guo Y, et al. The expression of novel gene GYLZ-RCC18 in renal cell carcinoma and its clinical significance. Chin J Urol. 22(4):197-9. 2001.
18. Zhang Q, Zhang Z, Guo Y, et al. Cloning and identification of renal cell carcinoma relative novel gene GYLZ-RCC18. Chin Med J. 115(5):746-9. 2002.
19. Zhang Q, Rubenstein JN, Liu VC, Park I, Jang T, Lee C. Restoration of expression of transforming growth factor-beta type II receptor in murine renal cell carcinoma (renca) cells by 5-Aza-2'-deoxycytidine. Life Sci. 76(10):1159-66. 2005.
20. Zhang Q, Yang X, Greenberg NM, Lee C. Adoptive transfer of tumor-reactive TGF-beta-insensitive CD8+ T cells: eradication of autologous mouse prostate cancer. Cancer Res. 65(5):1761-9. 2005.
21. Zhang Q, Rubenstein J, Jang T, et al. Insensitivity to transforming growth factor-beta results from promoter methylation of cognate receptors in human prostate cancer cells (LNCaP). Molecular Endocrinology. 19(9):2390-2399. 2005.
22. Zhang Q, Yang X, Pins M, et al. Infiltration of tumor-reactive transforming growth factor-beta insensitive CD8+ T cells into the tumor parenchyma is associated with apoptosis and rejection of tumor cells. Prostate. 66(3):235-47. 2006.
23. Zhang Q, Zhou W, Jang T, et al. Leader sequence triggers and enhances multiple functions of clusterin and is instrumental in the progression of human prostate cancer in vivo and in vitro. BJU International. 98(2):452-60. 2006.
24. Zhang Q, Kundu S, Yang X, et al. Blockade of TGF-beta signaling in tumor-reactive CD8+ T cells activates the anti-tumor immune response cycle. Molecular Cancer Therapeutics. 5(8):1733-1743. 2006.

 Books

1. Zhongcheng Xin, Yinglu Guo, Qiang Zhang. Surgery Therapy for Dysfunction of Male Erection. Beijing, PRC; Beijing Medical University Publishing Company; 2001.

Contact Information

Northwestern University, Feinberg School of Medicine
Department of Urology
303 East Chicago Avenue, Tarry 16-703
Chicago, IL 60611-3008
(312) 908-7963
Fax (312) 908-7275
q-zhang2@northwestern.edu

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Department of Urology
Northwestern University, Feinberg School of Medicine
303 East Chicago Avenue, Tarry 16-703
Chicago, IL 60611-3008
(312) 908-8145/ Fax (312) 908-7275 E-mail: m-grant@northwestern.edu