One aspect of our research involves investigating the impact of scaffolding on tissue regeneration. We have previously investigated subintestinal submucosa (SIS), which is a biologically-derived decellularized matrix taken from porcine tissue. SIS provides an environment for cell infiltration which is very similar to native ECM. Many of the native growth factors and structural proteins are retained after SIS processing. We, along with many other researchers, have demonstrated the potential for bladder tissue repair using SIS.
We are also investigating synthetic tissue scaffolds, specifically a family of peptide-amphiphile (PA) molecules which self-assemble to form nanoscale fibers. These nanofibers can be used to deliver growth factors or other biological molecules to a site of interest. We use these molecules as self-supporting gels or as coatings on more traditional polymeric scaffolds, such as those made from poly(lactic-glycolic acid) (PLGA). We expect that these synthetic systems may allow for better control over the factors that influence tissue regeneration. In addition, our use of nanotechnology in collaboration with the Stupp group allows us to explore properties that aren’t accessible from conventional biomaterials.
