Amareshwar Singh, Ph.D.

Assistant Professor, Research
Division of Hematology/Oncology
Northwestern University Feinberg School of Medicine                                        
a-singh@northwestern.edu
312-503-0834

Research Interest

Research Description

The homeostasis of reactive oxygen species (ROS) is critical in cell signaling and the regulation of programmed cell death or apoptosis. The regulation of redox reactions significantly influences signaling and metabolic pathways in a cell.  An increase in the generation of ROS may activate downstream caspases leading to apoptotic cell death. This is an important approach in cancer therapy. Applying such novel approaches and using experimental agents we are investigating the mechanisms of reactive oxygen species (ROS) mediated apoptosis in myeloma and lymphoma. We are looking at both the intrinsic and extrinsic caspase system and the role of ROS in cellular signaling.

Recent Publications

Singh, A.T.K., Frohman, M.A., and Stern, P.H.  Parathyroid Hormone Stimulates Phosphatidylethanolamine Hydrolysis by phospholipase D in Osteoblastic Cells.  Lipids (in press).

Singh, A.T.K., Gilchrist, A., Voyno-Yasenetskaya, T., and Stern, P.H.  Gα12/ α13 subunits of heterotrimeric G proteins mediate parathyroid hormone activation of phospholipase D in UMR-106 osteoblastic cells.  Endocrinology May;146(5):2171-5, 2005. 

Radeff, J.M., Singh, A.T.K., Stern, P.H.  Role of protein kinase A, phospholipase C and phospholipase D in parathyroid hormone receptor regulation of protein kinase C and interleukin-6 in UMR-106 osteoblastic cells.  Cellular Signaling 16:105-114, 2004. 

Singh, A.T.K., Bhattacharyya, R.S., Radeff, J.M., Stern, P.H.  Regulation of parathyroid hormone-stimulated phospholipase D in UMR-106 cells by calcium, MAP Kinase and small G proteins.  J Bone Miner Res 18:1453-1460, 2003.

Rainwater, D.L., Kammerer, C.M., Singh, A.T.K., Moore, Jr., P.H., Poushesh, M., Shelledy, W.R., VandeBerg, J.F., Robinson, E.R., VandeBerg, J.L.  Genetic control of lipoprotein phenotypes in the laboratory opposum, Monodelphis domestica.  GeneScreen 1(3): 117-124, 2001.

Singh, A.T.K., Radeff, J.M., Kunnel, J.G., Stern, P.H.  Phosphatidylcholine specific-phospholipase C inhibitor, tricyclodecan-9-yl-xanthogenate (D609), increases phospholipase D-mediated phosphatidylcholine hydrolysis in UMR-106 osteoblastic osteosarcoma cell.  Biochim Biophys Acta 1487: 201-208, 2000.