A. Vania Apkarian, PhD
Professor of Anesthesiology
Training / Education
Undergraduate
University of Southern CaliforniaResearch Fellowship
Wurzburg University, Wurzburg, Germany (Humboldt Fellowship)
Research & Bibliography
Research Grants
$310,440 National Institute of Neurological Disorders and Stroke Grant for "Cortical Dynamics for Pain Reception in Behaving Rats" study (2003)
Original, Peer-Reviewed Research Publications
Grachev ID, Fredericksen BE, Apkarian AV. Brain chemistry reflects dual states of pain and anxiety in chronic low back pain. J Neural Transm. 2002 Oct;109(10):1309-34.
Khan SA, Apkarian AV. Mastalgia and breast cancer: a protective association? Cancer Detect Prev. 2002;26(3):192-6.
Khan SA, Apkarian AV. The characteristics of cyclical and non-cyclical mastalgia: a prospective study using a modified McGill Pain Questionnaire. Breast Cancer Res Treat. 2002 Sep;75(2):147-57.
Apkarian AV, Krauss BR, Fredericksen BE, Szeverenyi NM. Imaging the pain of low back pain: Functional MRI in combination with monitoring subjective pain perception allows the study of clinical pain-states. Neurosci. Letters. 2001;299:57-60.
Apkarian AV, Thomas S, Krauss BR, Szeverenyi NM. Prefrontal cortical hyperactivity in patients with sympathetically mediated chronic pain. Neurosci Lett. 2001 Oct 5;311(3):193-7.
Grachev ID, Apkarian AV. "Chemical network of the living human brain. Evidence of reorganization with aging." Cognitive Brain Research 11"185-197, 2001.
Apkarian AV, Krauss BR, Fredericksen BE, Szeverenyi NM. "Imaging the pain of low back pain: Functional MRI in combination with monitoring subjective pain perception allows the study of clinical pain-states." Neurosci. Letters 299:57-60, 2001.
Grachev ID, Swarnkar A, Szeverenyi NM, Ramachandran TS, Apkarian AV. "Aging alters the multichemical networking profile of the human brain: an in vivo 1H-MRS study of young versus middle-aged subjects. J. of Neurochemistry 77:292-303, 2001.
Grachev ID, Fredericksen BE, Apkarian AV. "Dissociating anxiety from pain. Mapping neuronal marker N-acetyl-aspartate to perception distinguishes closely interrelated characterisitics of chronic pain." Molecular Psychol. 6:256-260, 2001.
Grachev ID, Apkarian AV. "Aging alters regional multichemical profile of the human brain: an in vivo H MRS study of young versus middle-aged subjects." J. of Neurochemistry 76:582-593, 2001.
Grachev ID, Apkarian AV. "Chemical heterogeneity of the living human brain: a proton MR spectroscopy study on the effects of sex, age, and brain region." NeuroImage 11:554-563, 2000.
Grachev ID, APkarian AV. "Chemical mapping of anxiety in the brain of healthy humans: an in vivo H MRS study on the effects of sex, age, and brain region." Human Brain Mapping 11:261-272, 2000.
Grachev ID, APkarian AV. "Anxiety in healthy humans is associated with orbital frontal chemistry." Molecular Psychiatry 5:482-488, 2000.
Apkarian AV, Grachev ID, Krauss BR, Szeverenyi NM. "New directions for studying human brain pathophysiology of chronic pain states." Disability 9:17-23, 2000.
Treede R, Apkarian AV, Bromm B, Greenspan JD, Lenz FA. "Cortical representation of pain: functional characterization of nociceptive areas near the lateral sulcus." Pain 87:113-119, 2000.
Brüggemann J, Galhardo V, Apkarioan AV. "Immediate reorganization of the rat somatosensory thalamus following peripheral partial nerve ligation." J. of Pain, 2000.
Apkarian AV, Gelnar PA, Krauss BR, Szeverenyi NM. "Cortical responses to thermal pain depend upon stimulus size: an fMRI study." J. Neurophysiology 83:3113-22, 2000.
Bolanowski SJ, Maxfield LM, Gescheider GA, Apkarian AV. "The effects of stimulus location on the gating of touch by heat- and cold- induced pain." Somatosens. and Motor Res. 17:195-204, 2000.
Apkarian AV, Shi T, Brüggemann J, Airapetian LR. "Segregation of nociceptive and non-nociceptive networks in the squirel monkey somatosensory thalamus." J. Neurophysiology 84:484-494, 2000.
Grachev ID, Apkarian AV. "Chemical heterogeneity of the living human brain: a proton MR spectroscopy study on the effects of sex, age, and brain region." NeuroImage 11:554-563, 2000.
Grachev ID, Fredericksen BE, Apkarian AV. "Abnormal brain chemistry in chronic back pain" an in vivo proton magnetic resonance spectroscopy study." Pain 89:7-18, 2000.
Invited Presentations
"Chronic pain and cortical dysfunction." German Pain Societ Meeting, Hamburg, Germany, October 2000.
"Prefrontal abnormalities in CRPS patients." International Association for the Study of Pain Symposium on CRPS, Cardiff, Wales, October 2000.
"Thalamocortical dynamics of interactions between the senses of touch and pain." Winter Conference on Brain Research, January 2000.
Abstracts
Grachev ID, Apkarian AV. "Chemical network of the human brain: evidence of reorganization with aging." Proc. 6th Annual Meeting Organization for Human Brain Mapping. San Antonio, Texas, 2000.
Kumar R, Grachev ID, Apkarian AV. "Relationship between cognitive performance and brain chemistry in chronic back pain." Soc. Neurosci 26: 2000.
Apkarian AV, Grachev ID. "Chemical mapping of anxiety in the brain of healthy humans: an in vivo H MRS study on the effects of sex, age, and brain region." Soc. Neurosci 26: 2000.
Grachev ID, Fredericksen BE, Apkarian AV. "Dissociating anxiety from pain. Mapping neuronal marker N-acetyl-aspartate to perception distinguishes closely interrelated characterisitics of chronic pain." Soc. Neuroscience 26:2000.
email: a-apkarian@northwestern.edu